Journal article
Family-based association study of IGF1 microsatellites and height, weight, and body mass index
G Fehringer, H Ozcelik, JA Knight, AD Paterson, GS Dite, GG Giles, MC Southey, IL Andrulis, JL Hopper, NF Boyd
Journal of Human Genetics | NATURE PUBLISHING GROUP | Published : 2010
DOI: 10.1038/jhg.2010.17
Abstract
Height, weight, and body mass index (BMI) are partly heritable, known to be associated with chronic diseases, and are linked to circulating insulin-like growth factor I (IGF-I) concentrations. IGF-I concentrations are also partly heritable and thus genetic variation at IGF1 could influence height, weight, BMI and the risk of developing chronic diseases. Our objective was to examine the association of genetic variation at IGF1 with height, weight and BMI using a sample of premenopausal women. A family-based study design was used to investigate the association of three IGF1 CA repeat variants at 5′ (5′CA), intron 2 (In2CA) and 3′ (3′CA) with these anthropometric measures. We analyzed the data ..
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Awarded by National Cancer Institute
Funding Acknowledgements
We thank Hamdi Jarjanazi and Keith Wong for their contributions to this study. This work was supported by the National Cancer Institute, National Institutes of Health under RFA-CA-06-503 and through cooperative agreements with members of the Breast Cancer Family Registry and PIs (including PIs from Cancer Care Ontario (U01 CA69467) and the University of Melbourne (U01 CA69638)). The content of this paper does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the CFR, nor do mentions of trade names, commercial products or organizations imply endorsement by the US Government or the CFR. JLH is an Australia Fellow of the National Health and Medical Research Council (NHMRC) and a Group Leader of the Victorian Breast Cancer Research Consortium (VBCRC). MCS is a Senior Research Fellow of the NHMRC and a Group Leader of the VBCRC.